About
Biographies
Research Interests and Accomplishments
Phil Weyman is an Assistant Professor in the Synthetic Biology and Bioenergy department at JCVI. His research interests focus on developing synthetic biology techniques photosynthetic microorganisms to enhance bioenergy production. Recent research has focused on developing genome editing tools for diatoms, yeast-based DNA assembly methods to clone prokaryotic and eukaryotic chromosomes and engineering cyanobacterial strains with improved hydrogen production capabilities.
Before coming to JCVI, Phil was a postdoctoral researcher at the University of Missouri — St. Louis where he studied hydrogen production in nitrogen fixing cyanobacteria. Phil earned his Ph.D. from the University of California, Davis in Plant Pathology.
Select Publications
Yonemoto IT, Smith HO, et al.
Designed Surface Residue Substitutions in [NiFe] Hydrogenase That Improve Electron Transfer Characteristics.
International Journal of Molecular Sciences. 2015 Jul 01; 16: 2020-33.[more]
Karas BJ, Diner RE, et al.
Designer Diatom Episomes Delivered by Bacterial Conjugation.
Nature Communications. 2015 Jul 01; 6: 6925.[more]
Karas BJ, Suzuki Y, et al.
Strategies for Cloning and Manipulating Natural and Synthetic Chromosomes.
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of chromosome Biology. 2015 Feb 01; 23: 57-68.[more]
Yonemoto IT, Clarkson BN, et al.
A Broad Survey Reveals Substitution Tolerance of Residues Ligating FeS Clusters in [NiFe] Hydrogenase.
BMC Biochemistry. 2014 Jun 17; 15: 10.[more]
Xu Y, Weyman PD, et al.
Circadian Yin-yang Regulation and Its Manipulation to Globally Reprogram Gene Expression.
Current Biology : CB. 2013 Dec 02; 23: 2365-74.[more]
Yonemoto IT, Matteri CW, et al.
Dual Organism Design Cycle Reveals Small Subunit Substitutions That Improve [NiFe] Hydrogenase Hydrogen Evolution.
Journal of Biological Engineering. 2013 Sep 01; 7: 17.[more]
Karas BJ, Molparia B, et al.
Assembly of Eukaryotic Algal Chromosomes in Yeast.
Journal of Biological Engineering. 2013 Jul 01; 7: 30.[more]
Karas BJ, Jablanovic J, et al.
Direct Transfer of Whole Genomes from Bacteria to Yeast.
Nature Methods. 2013 May 01; 10: 410-2.[more]
Noskov VN, Karas BJ, et al.
Assembly of Large, High G+C Bacterial DNA Fragments in Yeast.
ACS Synthetic Biology. 2012 Jul 20; 1: 267-73.[more]
Vargas, W. A., Weyman, P. D., et al.
[NiFe] Hydrogenase from Alteromonas macleodii With Unusual Stability In the Presence of Oxygen and High Temperature
Appl Environ Microbiol. 2011 Mar 01; 77(6): 1990-8.[more]
Weyman, P. D., Pratte, B., et al.
Hydrogen Production In Nitrogenase Mutants In Anabaena variabilis
FEMS Microbiol Lett. 2011 Mar 01; 304(1): 55-61.[more]
Weyman, P. D., Vargas, W. A., et al.
Heterologous Expression of Alteromonas macleodii and Thiocapsa Roseopersicina [NiFe] Hydrogenases In Escherichia coli
Microbiology. 2011 Feb 24;[more]