Publications
Citation
Xu Y, Weyman PD, Umetani M, Xiong J, Qin X, Xu Q, Iwasaki H, Johnson CH
Circadian Yin-yang Regulation and Its Manipulation to Globally Reprogram Gene Expression.
Current Biology : CB. 2013 Dec 02; 23: 2365-74.
Abstract
The cyanobacterial circadian program exerts genome-wide control of gene expression. KaiC undergoes rhythms of phosphorylation that are regulated by interactions with KaiA and KaiB. The phosphorylation status of KaiC is thought to mediate global transcription via output factors SasA, CikA, LabA, RpaA, and RpaB. Overexpression of kaiC has been reported to globally repress gene expression.