This page provides SIFT predictions for a list of chromosome positions and alleles.

To ensure success database retrieval and speed up search time, use the Restrict to Coding Variants tool to trim your list of input coordinates so it only contains coding variants.

If the input size is greater than 1000 chromosome locations, upload your data using the 'upload file' option and provide a return email address.

Results are deleted after an hour, so please save them!

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PLEASE READ: If you do not receive a coding annototian and the variant has passed our coding filter, then our internal database had gene annotation discrepancies for that particular variant. Please convert variant coordinates to GRCh37, or check by hand.

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User Input

Select assembly/annotation version
Homo sapiens GRCh37 Ensembl 63 Homo sapiens GRCh37 Ensembl 55 Homo sapiens NCBI 36 Ensembl 41

Chromosome Coordinates
Paste in comma separated list of chromosome coordinates, orientation (1,-1) and alleles see [sample format]


-or-

Upload file containing chromosome coordinates and nucleotide substitutions (size limit: 100K rows)

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Enter your email address if you want the results through email :
Please check that your address is correct and your mailbox is not full.

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Output Options

Include the following fields in the output table
Ensembl Gene ID
Gene Name
Gene Description
Ensembl Transcript Status (Known / Novel)
Ensembl Protein Family ID
Ensembl Protein Family Description
Protein Family Size
Ka/Ks (Human-mouse)
Ka/Ks (Human-macaque)
OMIM Disease
Allele Frequencies (All Hapmap Populations - weighted average)
Allele Frequencies (CEU Hapmap population)
Note: ASW - YRI only available in Ensembl 63
Allele Frequencies (ASW Hapmap population)
Allele Frequencies (CHB Hapmap population)
Allele Frequencies (CHD Hapmap population)
Allele Frequencies (GIH Hapmap population)
Allele Frequencies (JPT Hapmap population)
Allele Frequencies (LWK Hapmap population)
Allele Frequencies (MEX Hapmap population)
Allele Frequencies (MKK Hapmap population)
Allele Frequencies (TSI Hapmap population)
Allele Frequencies (YRI Hapmap population)

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