SIFT dbSNP Protein provides SIFT predictions for a list of RefSeq IDs or gi numbers and their corresponding amino acid substitutions. If no amino acid substitution is listed, prediction for dbSNP 132 nonsynonymous variants will be returned.

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User Input

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Protein IDs
One RefSeq accession (starting with XP / NP) or gi number per line (Limit 1000 proteins, please!).
[Sample format]

Paste in RefSeq accessions or gi numbers


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Upload file containing RefSeq accessions or gi numbers

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Select sequences to include: all BLAST hits best BLAST hit to each organism
If you receive a warning that the sequences were not diverse enough for prediction on your substitution, try "all BLAST hits". If that fails, you can submit here and have SIFT find the appropriate number of sequences.

Remove sequences more than percent identical to query
This cleans out any polymorphic alleles (sequences in the database that are nearly identical to your protein but already containing the substitutions of interest). The contaminating sequences may cause the substitution to be predicted as tolerated.

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