This tool provides SIFT predictions for a given protein FASTA sequence by using related sequences provided by the user. Your query sequence is the sequence that you would like prediction on (i.e. the sequence in which you have introduced the amino acid substitutions). The query sequence must be first among the related sequences you enter. The protein sequences will be aligned by PSI-BLAST. If your protein sequences are already aligned, submit your aligned sequences.
User Input
Enter your protein query sequence along with related sequences (not necessarily aligned). These sequences are assumed to be functional, and is what SIFT will base its prediction on. The normal (functional) query sequence should appear first. Name of file containing protein query sequences (fasta format).
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